Disease Severity And Renal Function Among Sickle Cell Anaemia Patients In A Tertiary Hospital, South-south, Nigeria: A Cross Sectional Study

Author: Ajeigbe K Abiodun1*, Adejumo Oluseyi2 , OwojuyigbeTemilola3 , Ayinbuomwan Ekiye4 , Okesina A Bashiru5

Year: 2023

Category: Unpublished Journals

Abstract

Sickle cell anaemia (SCA) is a chronic sickling disease characterized by clinical events called crisis1 . These clinical events are modified by factors such as hydration, de-oxygenation, temperature, pH, viscosity, levels of haemoglobin F, and co-existing haemoglobinopathies such as thalassemia and glucose-6-phosphate dehydrogenase deficiency2 . Individuals with SCA are at risk of developing renal disease due to chronic sickling underlying the disease and resulting in hemolysis-induced renal injury3 . Chronic kidney disease (CKD) is a recognized complication of SCA associated with risk factors such as hypertension, low haemoglobin concentration, hemolysis, prior vaso-oclusive crisis, BS gene haplotype4-9. Renal involvement contributes substantially to reduced life expectancy in patients with SCA, accounting for 16-18% mortality10.

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